Whole-body molecular and cellular mapping of the laboratory mouse - PubMed
4 hours ago
- #Whole-body Mapping
- #Mouse Model
- #Spatial Transcriptomics
- Spatiotranscriptomics profiles were generated from whole-mouse sections to capture histological regions.
- A reference dataset of 59 million single cells and a computational method enabled spatial assignment of 379 cell types.
- The LABEL machine learning pipeline was developed to annotate tissues and cell types on H&E-stained histology images across the body.
- Whole-mouse spatial profiling mapped systemic inflammation in endotoxemia, revealing organism-wide gene expression changes.