Biophysical Modeling Elucidates Mechanistic Principles for Rational Molecular Glue Design - PubMed
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- Biophysical modeling establishes a mathematical framework for understanding molecular glues dynamics.
- Binding affinity of ternary complex is key for performance of glue degraders and stabilizers.
- Degrader efficiency limited by catalytic rate and target protein's natural half-life.
- Effector abundance relative to target is critical for stabilizers, less so for degraders.