Neuro-tumor-immune crosstalk in pancreatic cancer: Mechanisms and therapeutic insights - PubMed
5 hours ago
- #Pancreatic cancer
- #Cancer neuroscience
- #Neuro-tumor-immune crosstalk
- The nervous system plays a central role in maintaining physiological homeostasis and interacts bidirectionally with tumor cells and the immune system.
- Pancreatic cancer, known as the 'king of cancers,' is aggressive, exhibits early perineural invasion, and has a poor prognosis.
- The neuro-tumor-immune microenvironment involves neurotransmitters, neurotrophic factors, and synaptic remodeling, promoting cancer cell migration and immunosuppression.
- Cancer cells and the immune microenvironment can reshape neural structures, worsening immune evasion and disease progression.
- The review proposes neuroscience-guided precision therapies, including biomarkers for neural invasion and targeting key interaction nodes in neuro-tumor-immune crosstalk.
- These strategies aim to overcome therapeutic challenges in pancreatic cancer and translate research into clinical applications.