NRF2 as a Therapeutic Target in Dermatological Disorders: Mechanisms and Molecules - PubMed
9 hours ago
- #NRF2
- #oxidative stress
- #dermatological disorders
- NRF2 is a key transcription factor that regulates cellular defense against oxidative and electrophilic stress.
- Dysregulation of the KEAP1-NRF2-ARE pathway is linked to dermatological disorders such as vitiligo, psoriasis, atopic dermatitis, photoaging, and radiation dermatitis.
- Various pharmacological and natural compounds, including isothiocyanates, triterpenoids, flavonoids, alkaloids, glycosides, stilbenoids, and fumaric acid esters, show potential as NRF2 activators.
- Dimethyl fumarate and tapinarof have advanced to clinical development or commercialization for treating skin conditions.
- NRF2 activation is a promising therapeutic strategy to combat oxidative stress-driven skin damage and inflammation.