DGAT1 mediates sex-specific CD8+ T cell antitumour responses - PubMed
4 hours ago
- #DGAT1
- #sex-specific immunity
- #CD8+ T cells
- DGAT1 plays a sex-specific role in CD8+ T cell antitumour responses.
- In female mice, DGAT1 deficiency enhances mitochondrial fitness and expands progenitor exhausted CD8+ T cells, improving antitumour responses.
- In male mice, DGAT1 deficiency leads to fatty acid peroxidation, ER stress, and CD8+ T cell death, mediated by androgen receptor (AR) signalling.
- Interventions like AR deletion, GPX4 overexpression, or ER stress inhibition can rescue DGAT1-deficient CD8+ T cell survival in male mice.
- The study highlights sex-specific metabolic adaptations in the tumour microenvironment and DGAT1's role in protecting against ER stress in male T cells.