Induced Sputum Multi-Omics Reveals Airway Signatures of COPD in Smokers: A Pilot Study - PubMed

6 hours ago

COPD is a leading cause of mortality worldwide, with only a fraction of smokers developing the disease.
The study analyzed induced sputum from smokers with and without COPD using proteomics, metabolomics, and lipidomics.
Key findings include increased glutathione, creatine, and L-arginine in COPD patients, along with lipid remodeling.
STAT3 was identified as a highly connected node in network analysis, linking COPD-related genes.
The study suggests multi-omic profiling can capture airway-localized molecular signatures like oxidative stress and cytoskeletal remodeling.
Results are exploratory and require further validation through functional studies.

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