Rare coding variants in CHRNB3 associate with reduced daily cigarette smoking across ancestries - PubMed
4 hours ago
- #genetics
- #CHRNB3
- #smoking
- Rare coding variants in CHRNB3 gene are associated with reduced daily cigarette smoking.
- A deleterious missense variant (p.Glu284Gly) in CHRNB3 significantly reduces cigarette consumption, enriched in Indigenous Mexican ancestry.
- A predicted loss-of-function variant in CHRNB3 also reduces cigarette smoking, found in East Asian ancestry.
- Rare deleterious variants in CHRNB3 collectively associate with lower cigarette consumption in European ancestry.
- Findings suggest β3 inhibition as a potential therapeutic strategy for nicotine addiction.
- Authors include employees/stockholders of Regeneron Pharmaceuticals, with related patent applications.