Omega-3 fatty acids improve lipid metabolism by regulating miR-34a - PubMed
4 days ago
- #miR-34a
- #Omega-3 fatty acids
- #Lipid metabolism
- Omega-3 fatty acids improve lipid metabolism and reduce hepatic lipid deposition.
- Omega-3 fatty acids down-regulate miR-34a expression, which is upregulated in high-fat diet (HFD) and palmitic acid (PA) models.
- Intervention with omega-3 fatty acids reduces serum levels of TG, TC, and LDL-C, and decreases liver TG and TC levels.
- Omega-3 fatty acids decrease miR-34a and SREBP-1c expression while increasing SIRT1, PGC-1α, and CPT-1A expression.
- Overexpression of miR-34a inhibits the beneficial effects of omega-3 fatty acids on lipid metabolism-related genes.
- The study suggests omega-3 fatty acids as a potential therapeutic for metabolic diseases like non-alcoholic fatty liver disease (NAFLD).