Maternal Acetaminophen Use and Child Neurodevelopment - PubMed
4 days ago
- #neurodevelopment
- #pregnancy
- #acetaminophen
- Study examines maternal acetaminophen use during pregnancy and its association with ADHD and autism spectrum disorders (ASDs) in offspring.
- Cohort study in Taiwan analyzed 2,092,926 singleton births (2004-2015), with 48.3% exposed to at least 2 acetaminophen prescriptions.
- In the full cohort, prenatal acetaminophen use was associated with increased ADHD (0.06%) and ASD (0.01%) diagnoses.
- Sibling-matched analyses showed no overall association, but divergent results when comparing older vs. younger sibling exposures.
- Older sibling exposure linked to higher ADHD/ASD risk, while younger sibling exposure showed reduced risk.
- Findings suggest potential biases in sibling analyses, preventing definitive conclusions.