E3 ubiquitin ligase Stub1 enhances viral replication by promoting TBK1 degradation through molecular chaperone-mediated autophagy - PubMed
5 hours ago
- #autophagy
- #innate immunity
- #viral replication
- E3 ubiquitin ligase Stub1 promotes TBK1 degradation via chaperone-mediated autophagy (CMA), inhibiting type I interferon production and enhancing viral replication.
- Stub1 catalyzes K27-linked polyubiquitination of TBK1 at lysine 344, facilitating recognition by HSC70 and degradation through LAMP2A-mediated CMA.
- Stub1-deficient mice show greater resistance to VSV and HSV-1 infections with elevated type I IFN levels, underscoring Stub1's role in suppressing antiviral innate immunity.