Dynamic subcellular proteomics identifies regulators of adipocyte insulin action - PubMed
5 hours ago
- #adipocytes
- #insulin
- #proteomics
- Insulin regulates adipocyte functions like suppressing lipolysis and increasing glucose uptake.
- Subcellular proteomics reveals extensive insulin-stimulated protein relocalization in adipocytes.
- C3ORF18, an uncharacterized protein, moves to the plasma membrane upon insulin stimulation and is essential for adipocyte insulin sensitivity.
- The study provides a resource for understanding how protein localization changes contribute to insulin responses.
- No competing interests declared by the authors.
- Supported by grants from Medical Research Council, Wellcome Trust, and other funding bodies.