Predicting Disease Progression and Survival in Amyotrophic Lateral Sclerosis - PubMed
5 hours ago
- #respiratory phenotyping
- #ALS
- #disease progression
- ALS is a relentless neurodegenerative disease with a median survival of 2-5 years post-symptom onset.
- Significant phenotypic heterogeneity and variable disease progression complicate treatment timing and clinical trial design.
- Early respiratory phenotyping is proposed as a method to improve patient stratification and predict survival.
- Forced Vital Capacity (FVC) is highlighted as an indicator of survival and disease progression in ALS.
- The study underscores the challenges in measuring the impact of interventions due to disease variability.