Plasma Extracellular Vesicle Surface Marker Profiling Reveals Immune Cell-Associated Mitochondrial Membrane Potential Alterations in Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome -
3 hours ago
- #Long COVID
- #Extracellular Vesicles
- #ME/CFS
- Plasma extracellular vesicles (EVs) from individuals with Long COVID (LC) and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) show elevated concentrations compared to COVID-recovered controls.
- Leukocyte-, monocyte/macrophage-, and platelet-derived EVs were increased, while B cell-derived EVs were reduced in both pan-ME/CFS and LC-ME/CFS groups.
- Increased mitochondrial membrane potential was observed in B cell-, monocyte/macrophage-, and NK cell-derived EV subsets in pan-ME/CFS, suggesting immune-metabolic involvement, with B cell-associated changes also seen in prepandemic ME/CFS.
- EV profiling captures shared molecular signatures between LC and ME/CFS, indicating potential for biomarker development in these overlapping conditions.