Decoding Skin Aging: Emerging Roles of miRNAs, lncRNAs, and circRNAs in Mechanisms, Therapies, and Future Horizons - PubMed
3 days ago
- #Non-coding RNAs
- #Skin aging
- #Precision dermatology
- Skin aging is influenced by intrinsic and extrinsic factors like cellular senescence, photoaging, glycation, and impaired wound healing.
- Non-coding RNAs (ncRNAs), including miRNAs, lncRNAs, and circRNAs, play key roles in regulating skin homeostasis, regeneration, and aging.
- Key ncRNAs such as miR-146a, miR-296-5p, lncRNA-H19, lncRNA-PVT1, and circRNA-406918 target molecules like SIRT1, AQP3, NAMPT, TLR4, and CTSD.
- These ncRNAs coordinate signaling via pathways such as PI3K/mTOR, AMPK/NAD+/SIRT, and ERK/p38 MAPK.
- ncRNAs are emerging as diagnostic biomarkers and therapeutic candidates in precision dermatology.
- Despite preclinical promise, clinical applications remain limited, highlighting the need for more human-focused research.