Nanoscopic tau aggregates are not shared intermediates but disease-specific entities across tauopathies - PubMed
11 hours ago
- #tauopathies
- #neurodegenerative diseases
- #tau aggregates
- Nanoscopic tau aggregates are disease-specific, not shared intermediates, across tauopathies.
- Small tau aggregates vary in abundance, morphology, and post-translational modifications depending on the disease.
- Alzheimer's disease (AD) features long, fibrillar-shaped tau aggregates enriched in phospho-epitopes.
- Progressive supranuclear palsy (PSP) has shorter, round tau aggregates selectively phosphorylated at serine 356.
- Serine 356 phosphorylation in PSP correlates with inflammation and apoptosis markers.
- Aggregate properties align with disease-specific seeding profiles and cellular stress signatures.
- Small tau aggregates may serve as biomarkers and therapeutic targets for tauopathies.