Amygdala astrocyte senescence drives stress-induced anxiety and hyperglycemia - PubMed
6 hours ago
- #hyperglycemia
- #chronic stress
- #astrocyte senescence
- Chronic stress leads to anxiety and hyperglycemia, a risk factor for type 2 diabetes.
- Stress induces hyperglycemia and astrocyte senescence in the amygdala in mice.
- Astrocyte senescence is caused by HK2 reduction via PBX1 transcription factor.
- HK2 deletion in astrocytes results in anxiety-like behaviors and hyperglycemia.
- HK2 reduction disrupts serine shuttle, lowering neuronal D-serine in the amygdala.
- Low D-serine imbalance sympathetic-parasympathetic amygdala-pancreas projections, causing hyperglycemia.
- L-serine supplementation or senolytic drugs (dasatinib/quercetin) alleviate stress-induced symptoms.