Epstein-Barr virus reprograms immune escape in nasopharyngeal carcinoma - PubMed
2 hours ago
- #immune escape
- #Epstein-Barr virus
- #nasopharyngeal carcinoma
- EBV-associated NPC features an immunosuppressive, immune-rich tumor microenvironment.
- Viral latent proteins like LMP1 activate NF-κB and JAK-STAT, promoting cytokine production and immune reprogramming.
- This leads to upregulation of multiple immune checkpoints, T-cell dysfunction, and myeloid suppression.
- Limited efficacy of anti-PD-1 therapies due to alternative checkpoints (e.g., TIM-3, LAG-3) and stromal barriers.
- Emerging strategies target both host immunity and EBV signaling to overcome immune escape and improve immunotherapy outcomes.