Engineering MnPt Bimetallic Nanozymes for Cascade Enzymatic Therapy and Enhanced Radio-Immunotherapy - PubMed
5 hours ago
- #radioimmunotherapy
- #nanozyme
- #cGAS-STING
- Development of a hyaluronic acid-coated manganese-platinum (MnPt) bimetallic nanozyme (HD@MnO2) for enhanced radioimmunotherapy in breast cancer.
- HD@MnO2 integrates enzymatic cascade initiation with cGAS-STING pathway activation to overcome immunosuppressive tumor microenvironment (TME).
- The nanozyme features multienzyme-like activity, enhancing H2O2 utilization, depleting glutathione, and promoting O2 generation, leading to ROS production and immunogenic cell death.
- Mn2+ release activates the cGAS-STING pathway, boosting innate immunity and promoting dendritic cell maturation and CD8+ T cell infiltration.
- In vitro and in vivo experiments show HD@MnO2 effectively eliminates primary tumors and suppresses metastatic tumors by overcoming radioresistance and eliciting systemic antitumor immunity.