Inflammation, cell death, and lncRNAs: unraveling the mechanisms of sepsis-associated acute kidney injury - PubMed
3 hours ago
- #SA-AKI
- #inflammation
- #lncRNAs
- Sepsis-associated acute kidney injury (SA-AKI) is a severe complication of sepsis with high morbidity and mortality.
- The pathogenesis of SA-AKI involves dysregulated inflammation, oxidative stress, and various forms of programmed cell death.
- Long non-coding RNAs (lncRNAs) play a critical role in regulating inflammatory signaling, oxidative stress, and cell fate decisions in SA-AKI.
- LncRNAs can act as either pathogenic amplifiers or protective modulators in renal injury, highlighting their complexity and clinical relevance.
- Potential applications of lncRNAs include their use as diagnostic biomarkers or therapeutic targets for SA-AKI.