fMRI-guided V1-targeted rTMS improves depressive symptoms in adolescents and young adults with bipolar disorder: a double-blind randomized controlled trial - PubMed
5 days ago
- #rTMS
- #bipolar disorder
- #fMRI
- fMRI-guided rTMS targeting the V1-OFC circuit improves depressive symptoms in adolescents and young adults with bipolar disorder.
- Double-blind randomized controlled trial with 52 participants, comparing active rTMS (10 Hz, 100% RMT) vs. sham (20% RMT) over 3 weeks (15 sessions).
- Primary outcome: Significant reduction in MADRS scores at week 8 in the active rTMS group (pFDR < 0.01).
- Secondary outcomes: Improvements in QIDS-SR and HAMD-24 scores, but no significant change in anxiety symptoms.
- Resting-state fMRI showed altered connectivity in the anterior cingulate cortex and right superior occipital gyrus.
- No severe adverse effects reported; protocol deemed safe and potentially effective.
- Study registered at ClinicalTrials.gov (NCT05929183) and approved by ethical committees.