Physical exercise modulates T cell activity and mitigates synaptic dysfunction in multiple sclerosis through vagus nerve engagement - PubMed
12 hours ago
- #multiple sclerosis
- #T cell activity
- #vagus nerve
- Physical exercise (PE) has beneficial effects in multiple sclerosis (MS) patients and in the experimental autoimmune encephalomyelitis (EAE) mouse model.
- PE improves EAE clinical outcomes by reducing neuronal damage and modulating T cell activity, including proliferation, activation, and metabolic function.
- Vagal nerve integrity plays a role in mediating PE-induced neuroimmune modulation, as shown by partial blunting of effects with cervical vagotomy.
- In progressive MS (PMS) patients, a structured PE program improved clinical outcomes and enhanced mitochondrial respiration in peripheral T cells.
- PE abolished glutamatergic synaptotoxicity induced by PMS-derived T cells, as revealed by patch-clamp recordings.
- The study highlights the therapeutic potential of PE in MS and identifies the vagal pathway as a key mediator of exercise-induced neuroimmune benefits.