Helicobacter pylori Infection and Risk of Chronic Obstructive Pulmonary Disease: A Meta-Analysis and Mendelian Randomization Study - PubMed
5 hours ago
- #COPD
- #Mendelian randomization
- #Helicobacter pylori
- Helicobacter pylori (H. pylori) infection is more prevalent in COPD patients compared to controls (RR = 1.43).
- H. pylori positivity in COPD patients is linked to poorer lung function (e.g., lower FEV1/FVC, FEV1%, FVC%).
- Mild-to-moderate COPD patients have a lower H. pylori infection rate than severe-to-very severe COPD patients (RR = 0.75).
- Mendelian randomization analysis found no genetic evidence of a causal relationship between H. pylori and COPD.
- The study does not recommend routine H. pylori screening or eradication therapy for COPD patients based on current evidence.