Dysesthesia associated with GLP-1 agonist therapies: data-mining analysis and literature review - PubMed
4 hours ago
- #GLP-1 agonists
- #pharmacovigilance
- #dysesthesia
- GLP-1 receptor agonists are associated with dysesthesia, including burning skin sensations.
- Data-mining found exenatide linked to hypoesthesia/oral paraesthesia, semaglutide and tirzepatide to hyperaesthesia, and semaglutide to dysesthesia/burning.
- Dysesthesia is dose-dependent, more common at higher doses and with potent agonists, regardless of use for weight or diabetes.
- Discontinuation often led to spontaneous favorable outcomes, with some cases of rechallenge observed.
- Evidence supports dysesthesia associated with GLP-1 agonists from pharmacovigilance data and clinical trials.