Global trends and forecasts of cervical cancer and a real-world safety assessment of human papillomavirus vaccines in women: A systematic analysis of the Global Burden of Disease study 2021 and the Va
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- #HPV Vaccines
- #Global Health
- #Cervical Cancer
- Global trends and forecasts of cervical cancer (CCA) were analyzed using Global Burden of Disease (GBD) 2021 data, showing a decrease in age-standardized incidence rate from 18.1 to 15.3 cases per 100,000 women from 1990 to 2021, but an increase in new cases from 0.41 million to 0.67 million.
- The highest incidence and death rates of CCA were observed in sub-Saharan Africa and selected Pacific Island countries, with projections suggesting continued declines in age-standardized incidence and death through 2050, though the absolute burden remains substantial.
- A real-world safety assessment of human papillomavirus (HPV) vaccines (Cervarix, Gardasil, Gardasil 9) was conducted using the Vaccine Adverse Event Reporting System (VAERS) database, identifying 41,731 reports, most of which were non-serious (80.9%).
- The most frequently reported adverse events following HPV vaccination were syncope, loss of consciousness, and pallor, with six potential designated medical event (DME)-related signals detected.
- The study underscores the need for sustained HPV vaccine prevention efforts supported by epidemiological evidence and transparent, evidence-based safety communication to address global disparities in CCA burden.