Epigenetic remodeling induced by fatty acids: chromatin modifications and cellular senescence during lipid overload - PubMed
10 hours ago
- #Epigenetics
- #Lipid Metabolism
- #Cellular Senescence
- Cellular senescence is a stable state maintained by specific gene expression programs linked to chromatin organization.
- Senescence programs depend on the inducing stimulus, with lipid overload emerging as a key metabolic stressor in conditions like obesity.
- Fatty acid-induced metabolic changes affect chromatin-modifying enzymes and remodelers through metabolites like acetyl-CoA, NAD+, and α-ketoglutarate.
- This review integrates evidence on how fatty acid-driven metabolic alterations reshape chromatin dynamics to promote and stabilize cellular senescence.