A neuron type-specific microexon in Ank3/ankyrin-G modulates calcium activity and neuronal excitability - PubMed
7 days ago
- #alternative splicing
- #calcium signaling
- #neuroscience
- A neuron type-specific microexon E35a in Ank3/ankyrin-G (AnkG) modulates calcium activity and neuronal excitability.
- E35a is predominantly skipped in cortical glutamatergic neurons but included in cortical GABAergic neurons and cerebellar neurons.
- E35a-deletion mice show increased excitability and somatic Ca2+ activity in interneurons without disrupting the axon initial segment (AIS).
- Biochemical analyses suggest E35a inclusion facilitates AnkG interaction with a protein complex involving inositol trisphosphate receptors (InsP3Rs), important for intracellular Ca2+ signaling.
- Alternative splicing allows AnkG to modulate neuron type-specific excitability in addition to its role in organizing the AIS.