Drug-coated Balloon Only Percutaneous Coronary Intervention For De-novo Chronic Total Occlusion: Insights From The Multicentre International CTO-DENOVO Registry - PubMed
5 days ago
- #Chronic Total Occlusion
- #Percutaneous Coronary Intervention
- #Drug-coated Balloon
- Study assesses drug-coated balloon (DCB)-only approach for chronic total occlusion (CTO) percutaneous coronary intervention (PCI).
- Retrospective multicenter international registry includes 309 patients with 312 CTO lesions from 42 sites.
- Primary endpoint was target lesion failure (TLF), with a rate of 3.5% at 6 months and no cardiac deaths.
- Secondary endpoints included binary restenosis (24.2%) and re-occlusion (4.0%).
- Positive vessel remodelling observed in 47.8% of cases with angiographic follow-up.
- Suboptimal predilatation linked to higher restenosis rates, warranting further investigation.
- DCB-only approach deemed safe for CTO treatment with low TLF at follow-up.