The Ratio of Immunogenicity: A quantitative metric to identify highly immunogenic protein antigens to improve tissue-engineered biomaterials - PubMed
6 hours ago
- #Biomaterials
- #Immunogenicity
- #Tissue Engineering
- Developed the Ratio of Immunogenicity (ROI) metric to quantitatively stratify protein antigens based on their relative immunogenicity.
- ROI combines immune response magnitude (IgG production) and antigen abundance to calculate a continuum of values.
- Mitochondrial antigens are significantly enriched in the top 25% (highly immunogenic), while cytoplasmic, extracellular, and vesicle-associated antigens are in the bottom 25% (weakly immunogenic).
- ROI helps identify highly immunogenic antigens to improve the design of immunologically acceptable tissue-engineered biomaterials.
- This metric challenges the assumption that all antigens are equally immunogenic and that total antigen reduction correlates with immune response.