A Systematic Review and Meta-Analysis of Semaglutide Effects on Adipose Tissue and Emerging Effects on Brain and Cognition - PubMed
5 hours ago
- #Adipose Tissue
- #Semaglutide
- #Cognitive Function
- Semaglutide (SEMA) shows potential benefits beyond obesity and diabetes, including Alzheimer's disease (AD) prevention.
- Systematic review and meta-analysis evaluated SEMA's effects on adipose tissue (SAT/VAT), brain function, and cognitive performance.
- 23 studies included: 18 on SAT/VAT outcomes, 5 on brain function and cognitive impairment.
- Meta-analysis found significant VAT reduction but no significant impact on SAT.
- SEMA demonstrated neuroprotective effects, lowering AD risk compared to other treatments.
- High heterogeneity observed across studies; SEMA may promote VAT loss and cognitive preservation.
- Further research needed to explore the sequence of VAT loss and cognitive preservation effects.