PTPN1 Regulation via YBX1-PTBP1 Interaction Promotes Fibroblast Activation and Fibrotic Remodeling in the Lung - PubMed
4 days ago
- #Pulmonary Fibrosis
- #YBX1-PTBP1 Interaction
- #Fibroblast Activation
- Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive lung disease with unknown causes.
- Fibroblast-to-myofibroblast transition (FMT) is crucial in the development of fibrosis in IPF.
- YBX1, a transcription factor, promotes TGF-β1-induced FMT and extracellular matrix (ECM) deposition in lung fibroblasts.
- YBX1 interacts with PTBP1 to regulate PTPN1 transcription, driving fibroblast activation and fibrosis.
- Inhibition of YBX1 suppresses TGF-β1-induced fibroblast migration and activation.
- In vivo, Ybx1-targeting shRNA delivered via AAV reduces ECM deposition and fibrosis markers in a bleomycin-induced mouse model.
- YBX1 is identified as a key promoter of lung fibrosis via the PTBP1/PTPN1 axis, suggesting potential therapeutic targets for IPF.