Frailty Trajectories and Incident Stroke Risk in People Aged 50 and Older: A Three-Cohort Prospective Analysis - PubMed
6 hours ago
- #Frailty
- #Stroke Risk
- #Aging
- The study analyzed data from three longitudinal cohorts (ELSA, HRS, CHARLS) to link frailty trajectories with stroke risk in adults aged 50+.
- Participants were classified into three frailty trajectory groups: Low, Moderate, and Increasing-to-high, based on a deficit-accumulation frailty index.
- Over a median follow-up of 7.5 years, 5.8% experienced incident strokes, with higher frailty trajectories associated with significantly increased stroke risk (HR 2.05 for Moderate, HR 3.51 for Increasing-to-high).
- The association was consistent across cohorts, suggesting frailty monitoring can aid in identifying individuals at elevated stroke risk for targeted prevention.