Evaluating the Safety of Creatine Monohydrate in Adolescents: A Systematic Review of Renal, Hepatic, and Cardiometabolic Outcomes - PubMed
4 hours ago
- #creatine monohydrate
- #adolescent safety
- #systematic review
- Creatine monohydrate is widely used as a dietary supplement for performance enhancement.
- Safety in adolescents remains a concern among clinicians and families.
- A systematic review conducted via PubMed (PRISMA guidelines) evaluated safety outcomes.
- Five studies (RCTs, cohort studies) from 2015-2025 met inclusion criteria.
- Creatine was well-tolerated in youth athletes and those with medical conditions.
- No consistent safety issues were found in renal, hepatic, or cardiometabolic markers.
- No serious adverse events were attributed to supplementation.
- Larger prospective studies with standardized dosing and longer follow-up are needed.