Dynamic Reconfiguration of Cognitive Networks and Recovery From Microlesion Effects in Parkinson's Disease: Insights From a Longitudinal fNIRS Study - PubMed
6 hours ago
- #Parkinson's disease
- #fNIRS
- #deep brain stimulation
- Bilateral subthalamic nucleus deep brain stimulation (STN-DBS) improves motor symptoms in advanced Parkinson's disease (PD).
- The perioperative 'microlesion effect' (MLE) is linked to cognitive dysfunction, particularly declines in verbal fluency (VFT).
- This study used longitudinal task-based fNIRS to track 20 PD patients undergoing STN-DBS at four critical time points.
- VFT scores dropped during MLE but partially recovered post-stimulation.
- MoCA scores also declined during MLE.
- Neuroimaging showed decreased activated channels during MLE, followed by reactivation post-stimulation, especially in prefrontal regions.
- DBS promotes functional reorganization of cognitive networks disrupted by MLE.
- fNIRS is a valuable tool for monitoring DBS-induced neuroplasticity in PD.