Traditional Chinese Medicine and Ferroptosis in Alzheimer's Disease: A Potential Therapeutic Approach - PubMed

5 hours ago

Alzheimer's disease (AD) is a major neurodegenerative disorder with no current cure.
Ferroptosis, a cell death process linked to iron dysregulation and lipid peroxidation, plays a key role in AD.
Traditional Chinese Medicine (TCM) shows potential in managing AD by targeting ferroptosis pathways.
TCM interventions include herbal extracts, monomers, compound formulas, and acupuncture.
Key targets include iron homeostasis, the system Xc-/GSH/GPX4 antioxidant system, and the Keap1/Nrf2/ARE pathway.
Current evidence is mostly preclinical, with challenges like blood-brain barrier penetration and standardization.
TCM offers promising avenues for AD treatment by modulating ferroptosis.

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