The Glymphatic System and Meningeal Lymphatics: Current Understandings and Future Perspectives - PubMed
21 hours ago
- #Glymphatic System
- #Neurological Disorders
- #Therapeutic Strategies
- The glymphatic-lymphatic axis is a brain-wide clearance network essential for CNS homeostasis and immune surveillance.
- It consists of the intramural glymphatic pathway for fluid transport and waste removal, and meningeal lymphatic vessels as efferent routes.
- Its function is regulated by factors like sleep and aging, with dysfunction linked to neurological disorders.
- Key disorders associated with its impairment include stroke (acute injury), Alzheimer's disease (chronic proteinopathy), and multiple sclerosis (autoimmune dysregulation).
- Emerging therapeutic strategies include pharmacological targets (e.g., VEGF-C, Piezo1 agonists), noninvasive neuromodulation (e.g., photo-biomodulation), and surgical interventions (e.g., lymphaticovenous anastomosis).