CXCL8 Drives MMP1 Upregulation and Promotes Metastatic Progression in Oral Cancer Through CXCR1/2-Mediated JAK1/STAT3 Activation - PubMed
2 days ago
- #OSCC
- #CXCL8
- #Metastasis
- CXCL8 is significantly upregulated in oral squamous cell carcinoma (OSCC) tissues and correlates with poor survival in head and neck cancer patients.
- CXCL8 promotes metastasis by upregulating MMP1 through activation of the CXCR1/2-JAK1-STAT3 signaling pathway.
- Inhibition of CXCR1/2, JAK1, STAT3, or MMP1 reverses CXCL8-induced cell migration and wound healing in OSCC cell lines.
- In vivo studies show that targeting CXCR1/2 reduces CXCL8 and MMP1 expression, limiting regional metastasis in OSCC.
- CXCL8 is identified as both a prognostic biomarker and a potential therapeutic target for preventing OSCC metastatic progression.