Brain Transcriptomics Across Diverse Sleep-Wake Manipulations Reveals Multiple Homeostatic Pathways in Drosophila - PubMed
5 hours ago
- #sleep homeostasis
- #Drosophila
- #transcriptomics
- Sleep is governed by circadian and homeostatic processes.
- The study aimed to identify 'slee-per' genes analogous to the circadian 'per' gene.
- Transcriptomic analysis in Drosophila brain across diverse sleep-wake manipulations was conducted.
- No single gene was consistently sleep-wake dependent across all datasets.
- Genes with consistent expression changes across at least 2 datasets were identified.
- Pathways like mitochondrial oxidative phosphorylation and ribosome biogenesis were highlighted.
- Genes correlated with sleep history or rebound were identified, showing temporal distinctions.
- Novel GPT-based algorithm fl.ai identified sleep-wake regulated genes with homeostatic functions.
- Sleep homeostasis involves distributed molecular processes, unlike the core circadian clock.