Prognostic stratification of cardiovascular risk and cardiac remodeling in prediabetes: a multimodal analysis comparing ADA and WHO/IEC diagnostic criteria - PubMed
4 hours ago
- #Diagnostic Criteria
- #Prediabetes
- #Cardiovascular Disease
- Prediabetes accelerates cardiovascular pathology independently through dysglycemia-driven mechanisms.
- The study compares ADA and WHO/IEC diagnostic criteria for prediabetes in cardiovascular risk stratification.
- Prediabetes, regardless of criteria, elevates CVD risk, with WHO/IEC showing stronger mortality associations.
- Mendelian randomization confirms prediabetes is causally linked to increased risks of CVD, coronary heart disease, myocardial infarction, stroke, and primary hypertension.
- Early concentric left ventricular remodeling is observed, particularly under WHO/IEC criteria.
- The findings emphasize the differential prognostic utility of ADA and WHO/IEC criteria in prediabetes for cardiovascular risk assessment.