Type 2 Endotypes in Airway Diseases - PubMed
5 hours ago
- #Type 2 Inflammation
- #Asthma
- #COPD
- Asthma and COPD are major chronic inflammatory airway diseases impacting health and society, recognized as complex syndromes with distinct phenotypes.
- Asthma is divided into T2-high and T2-low; over 50% are T2-high, including allergic and non-allergic eosinophilic endotypes.
- In COPD, typically non-T2, 20-30% show a T2 signature, defining T2-COPD endotype, involving eosinophilia and high FeNO.
- T2 inflammation involves epithelial and immune cells driving adaptive responses, with biologics approved for treatment in both diseases.
- For asthma, 6 T2-targeting biologics are approved; for T2 COPD, 2 biologics are approved, with others under evaluation.
- Emerging therapies include next-gen immunotherapy and trained immunity vaccines, aiming for better biomarkers and precision medicine.