Bacteroides coprocola protects dopaminergic neurons in rotenone-induced Parkinson's disease mouse model by modulating gut microbiota dysbiosis and inhibiting the NLRP3 signaling pathway - PubMed
5 hours ago
- #Parkinson's disease
- #NLRP3 inflammasome
- #Gut microbiota
- Bacteroides coprocola (B. coprocola) alleviates Parkinson's disease (PD) symptoms in a rotenone-induced mouse model.
- B. coprocola modulates gut microbiota dysbiosis and inhibits the NLRP3 inflammasome signaling pathway.
- Treatment with B. coprocola improves motor deficits, neuroinflammation, and intestinal barrier permeability in PD mice.
- Key metabolites acetate and butyrate from B. coprocola promote M2 macrophage polarization via FFAR2/3 receptors.
- In vitro studies confirm acetate and butyrate suppress NLRP3 activation and reduce inflammatory responses.