Fasting impairs humoral immunological memory by β-hydroxybutyrate-mediated depletion of plasma cells - PubMed
5 hours ago
- #vaccine effectiveness
- #fasting
- #immunological memory
- Fasting impairs humoral immunological memory by depleting long-lived plasma cells (LLPCs).
- β-hydroxybutyrate, a ketone body produced during fasting, mediates this effect by activating HCAR2 on plasma cells.
- Activation of HCAR2-Gαi-adenylate cyclase-cAMP axis downregulates CXCR4, causing plasma cells to exit bone marrow and undergo apoptosis.
- Memory B cells (MBCs) are spared during fasting, while LLPCs are selectively depleted.
- The study suggests diet and lifestyle could influence vaccine effectiveness by affecting humoral immunity.