Primary cilia regulate GLP-1 signaling in pancreatic β cells - PubMed
5 hours ago
- #Primary cilia
- #GLP-1 signaling
- #Pancreatic β cells
- Primary cilia play a crucial role in GLP-1 receptor (GLP-1R) signaling in pancreatic β cells.
- Loss of β-cell cilia in mouse and human islets significantly impairs GLP-1-potentiated insulin secretion.
- GLP-1R is localized to the primary cilium, as shown by immunofluorescence and immunogold scanning electron microscopy.
- Disrupting ciliary GPCR trafficking via Tulp3 knockdown mimics signaling and secretory deficits, highlighting the importance of the ciliary receptor pool.
- The study establishes primary cilia as essential for GLP-1R signaling and reveals new insights into incretin action in β cells.