The ageing immune system as a driver of systemic ageing - PubMed
8 days ago
- #healthspan
- #systemic ageing
- #immunosenescence
- The ageing immune system undergoes biochemical and functional changes leading to chronic inflammation, reduced immunity, and organ dysfunction.
- Immune cells in older individuals develop dysfunctional phenotypes: inflammatory, exhausted, or senescent, driven by hallmarks of ageing.
- Ageing immune cells contribute to multi-organ dysfunction and systemic ageing, suggesting potential health benefits from improving immune function in older individuals.
- The article reviews ageing effects on immune cell subsets in mice and humans, including molecular mechanisms and impacts on lymphoid and non-lymphoid organs.
- Therapeutic approaches to enhance ageing immune system function could increase resilience and extend healthspan.