Changes in frailty and its association with dementia risk in four prospective cohorts - PubMed
6 hours ago
- #dementia risk
- #frailty
- #aging research
- Baseline frailty is a known risk factor for dementia, but changes in frailty over time were less studied.
- This study analyzed data from four prospective cohorts (HRS, ELSA, CHARLS, SHARE) to examine frailty changes and dementia risk.
- Using the Fried frailty phenotype, participants were categorized as robust, pre-frail, or frail.
- Dementia was defined through cognitive and functional impairment or self-reported diagnosis.
- Progression from robust to pre-frail/frail was associated with increased dementia risk across all cohorts.
- Conversely, recovery from frail to robust/pre-frail was linked to reduced dementia risk compared to those remaining frail.
- The findings suggest that worsening frailty escalates dementia risk, while improvement in frailty status may lower it.