Role of oral-gut microbiota dysbiosis in regulating systemic impairment during age-related obesity: an animal study - PubMed
5 hours ago
- #microbiota
- #Romboutsia_B
- #obesity
- Study explores systemic effects of high-fat diet (HFD)-induced obesity across different ages in mice.
- HFD led to obesity, elevated blood lipids, liver enzymes, reduced blood oxygen, increased Aβ1-42 and LPS levels, and behavioral changes.
- HFD altered oral and gut microbiota diversity, enriching Romboutsia_B and depleting beneficial genera like Bifidobacterium and Akkermansia.
- Romboutsia_B abundance correlated with obesity, blood lipids, liver enzymes, hypoxia, and inflammatory markers, but negatively with cognitive-behavioral parameters.
- HFD enhanced lipid metabolism and environmental adaptation pathways while reducing polysaccharide degradation and vitamin metabolism.
- Romboutsia_B identified as a potential noninvasive microbial biomarker for obesity and its liver-brain comorbidities.