The gut and circulating virome: emerging players in aging and longevity - PubMed
6 hours ago
- #virome
- #longevity
- #aging
- The human virome, including gut and circulating viruses, plays a critical role in host physiology and aging.
- Age-related shifts in the virome include changes in bacteriophage families, latent virus reactivation, and persistence of viral pathobionts.
- These virome changes are linked to immunosenescence, chronic inflammation, and neurodegeneration.
- Centenarians exhibit a unique virome signature with increased diversity, lytic activity, and phage-encoded metabolic functions, suggesting a protective role in longevity.
- Challenges in virome research include technical biases, database limitations, and the presence of 'viral dark matter'.
- The review emphasizes the virome's relevance in Geroscience and discusses barriers to translating research into clinical aging studies.