CEBPB Expression in Tumor Cells Drives Immune Evasion in Colorectal Cancer via CTLA4 Up-regulation in T Cells - PubMed
6 hours ago
- #CEBPB
- #Immune Evasion
- #Colorectal Cancer
- CEBPB expression in tumor cells drives immune evasion in colorectal cancer (CRC).
- CEBPB is upregulated in TP53-mutated CRCs and negatively regulated by wild-type TP53.
- High CEBPB expression correlates with decreased T cell infiltration and worse patient survival.
- CEBPB expression in tumor cells is linked to increased CTLA4 expression in T cells, especially regulatory and exhausted T cells.
- Overexpression of Cebpb in mouse models promotes tumor growth and increases CTLA4 in CD4+ T cells.
- In vitro co-culture experiments confirm that tumor cell CEBPB increases CTLA4 in T cells.
- The findings suggest CEBPB's role in creating an immunosuppressive tumor microenvironment (TME).