Surgery versus Definitive Radiotherapy after Induction Immunochemotherapy for Stage II-III NSCLC: A Multicenter, Pragmatic Analysis - PubMed
7 hours ago
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- #immunochemotherapy
- Induction immunochemotherapy is standard for resectable stage II-III NSCLC.
- Study compares surgery vs. radiotherapy after induction immunochemotherapy.
- Multicenter retrospective cohort study with 967 patients (683 surgery, 284 radiotherapy).
- Surgery showed significantly longer PFS and OS compared to radiotherapy.
- Surgery reduced overall and local recurrence but not distant metastasis.
- For patients needing pneumonectomy, surgery improved PFS but not OS.
- Patients with clinical complete response (cCR) had similar outcomes in both groups.
- Surgery offers superior PFS and OS, primarily due to better local control.
- Individualized treatment recommended for pneumonectomy or cCR patients.
- Prospective trials are warranted for further validation.