Copper deficiency impairs oligodendrocyte maturation and social behavior via mitophagy and mTOR suppression in ASD - PubMed
5 hours ago
- #Oligodendrocyte maturation
- #Autism spectrum disorder
- #Copper deficiency
- Copper deficiency is linked to impaired social behavior and reduced white matter in autism spectrum disorder (ASD).
- A mouse model of copper deficiency shows disrupted oligodendrocyte development, oxidative stress, and mitochondrial dysfunction.
- Copper deficiency triggers BNIP3-mediated mitophagy and suppresses mTOR signaling, leading to hypomyelination.
- Restoring mTOR activity rescues oligodendrocyte maturation and social behavior in copper-deficient mice.
- The study identifies a copper-HIF1α-BNIP3-mTOR axis connecting trace element imbalance to ASD-related phenotypes.