Mitochondrial double-stranded RNA drives aging-associated cognitive decline - PubMed
7 days ago
- #cognitive decline
- #aging
- #mitochondrial RNA
- Mitochondrial double-stranded RNA (mt-dsRNA) drives aging-associated cognitive decline.
- SEC61A1 regulates ER-mitochondria contact sites, affecting mitochondrial DNA and RNA synthesis.
- Changes in mt-dsRNA lead to innate immune signaling activation in aging and Alzheimer's disease.
- Overexpression of Sec61a1 in the mouse cortex induces cognitive decline without affecting motor activity.
- Knockdown of Sec61a1 or Mavs alleviates cognitive decline in aging mice by blocking mt-dsRNA signaling.
- The study provides a potential therapeutic target for aging- and disease-associated cognitive decline.